https://proceeding.unikal.ac.id/index.php/pic en-US Proceeding International Conference and Community Service https://proceeding.unikal.ac.id/index.php/pic/article/view/2949 Anxiety disorder is a psychological condition related to mental disturbances, commonly treated with psychotropic medications that affect the brain and nervous system. Patient adherence to medication is critical for treatment effectiveness and relapse prevention. This study applies the Theory of Planned Behavior (TPB) to analyze factors influencing medication adherence among outpatients with anxiety disorders at the Psychiatric Clinic of Kraton Regional Hospital, Pekalongan. Using a cross-sectional design, data were collected from 68 patients diagnosed with anxiety and undergoing treatment with prescribed psychotropic drugs. A structured questionnaire was used to measure attitudes, subjective norms, and perceived behavioral control in relation to behavioral intention and medication adherence. Spearman correlation tests revealed significant relationships between adherence and intention (p=0.020, r=0.280), attitude and intention (p=0The results of the Spearman correlation test showed significant relationships between adherence and intention (p = 0.020, r = 0.280), attitude and intention (p = 0.000, r = 0.442), subjective norm and intention (p = 0.004, r = 0.348), and perceived behavioral control and intention (p = 0.000, r = 0.485). These findings indicate that patients' attitudes, social influences, and perceived control play important roles in shaping their intention and adherence to medication. In conclusion, strengthening these psychological factors through targeted interventions may improve adherence among patients with anxiety disorders Syifa Aldiena Ekanita Desiani Copyright (c) 1 01 1 8 https://proceeding.unikal.ac.id/index.php/pic/article/view/2959 Meniran leaves (Phyllanthus niruri L.) have antibacterial activity against Cutibacterium acnes. The aim of this study was to determine whether varying concentrations of stearic acid and triethanolamine as emulsifiers could affect the physical properties of meniran leaf extract cream formulations (Phyllanthus niruri L.) and to identify the optimal cream formulation. This was an experimental study. The cream formulation was prepared in three formulas with varying concentrations of stearic acid and triethanolamine, namely F1 (15% : 4%), F2 (16% : 3%), and F3 (17% : 2%). The evaluation of the cream formulations included organoleptic properties, pH, homogeneity, viscosity, spreadability, adhesion, irritation, and hedonic properties, as well as data analysis using the One-Way ANOVA method. The results of the analysis showed that variations in stearic acid and triethanolamine concentrations affected spreadability, adhesion, viscosity, and pH values. The best formula was F3 with stearic acid and triethanolamine concentrations of 17% : 2%. Elita Shafa Najwa Nur Cholis Endriyatno Copyright (c) 1 01 9 16 https://proceeding.unikal.ac.id/index.php/pic/article/view/2960 Urinary tract infection (UTI) is a condition caused by the presence of microorganisms in very large numbers in the urine and causes infections in the urinary tract. Bacterial resistance to antibiotics reduces the effectiveness of therapy. Bacterial sensitivity aims to determine whether the bacteria are resistant to various antibiotic preparations. The purpose of this study was to determine bacterial resistance and sensitivity in determining the effectiveness of antibiotics in UTI patients. This study research design used being descriptive observational through a design approach retrospective, to see the suitability of antibiotic use and bacterial sensitivity presentation data. Sampling using purposive sampling technique many as 40 samples based on information from medical records of UTI patients at “X” Regional Hospital then analyzed using SPSS and Microsoft Excel. The results of this study found UTI as the main diagnosis of 60% and 40% as a secondary diagnosis. The bacteria that cause UTI in this study were found to be 3 types of bacteria, the most dominant of which are Escherichia coli’s many as 20 patients (50%), Streptococcus sp many as 12 patients (30%) and Acinetobacter baumanniias many as 8 patients (20%). Escherichia coli resistant to the antibiotic cefixime (100%) and most sensitive to the antibiotic ciprofloxacin (100%). Streptococcus spresistant to the antibiotic cefixime (83%) and most sensitive to the antibiotic’s gentamicin and meropenem (92%). Acinobacter baumanniiresistant to the antibiotic cefixime as many as 5 people (62.5%) and most sensitive to the antibiotic trimethoprim-sulfamethoxazole as many as 7 people (87.5%) Nachma Vania Sabina S Ekanita Desiani Copyright (c) 1 01 17 24 https://proceeding.unikal.ac.id/index.php/pic/article/view/2961 Chronic Kidney Disease (CKD) is a progressive and irreversible condition with hypertension as a major contributing factor. Proper management of blood pressure is essential to prevent worsening renal function and improve patient outcomes. This study aimed to evaluate the use of antihypertensive drugs and their impact on therapy outcomes (Blood pressure, GFR, and QoL) in CKD patients at RSUD Bendan Pekalongan. This research employed a prospective observational method and involved 50 CKD outpatients receiving antihypertensive therapy. Data were collected over a two-month period through clinical measurements and patient-reported outcomes. Blood pressure, GFR and QoL were assessed before and after treatment. QoL was measured using the KDQOL-36 questionnaire. Data were analyzed using univariate and bivariate methods, including paired t-tests. The results showed that 96% of patients received combination therapy, most commonly involving diuretics, calcium channel blockers (CCB), and angiotensin receptor blockers (ARB). Average blood pressure decreased from 146/92 mmHg to 128/83 mmHg, GFR increased from 5.96 to 6.70 mL/min, and QoL scores improved from 288 to 348. These changes were statistically significant. In conclusion, antihypertensive therapy in CKD patients was effective in improving clinical outcomes, including blood pressure control, kidney function, and quality of life. The findings support the implementation of combination therapy as a standard approach in managing hypertension among CKD patients Azzahra Lusiana Putri Musa fitri fatkhiya Copyright (c) 1 01 25 33 https://proceeding.unikal.ac.id/index.php/pic/article/view/2962 <p>Ischemic stroke is the most common type of stroke, caused by an obstruction in the cerebral arteries, leading to neurological impairment. The use of neuroprotective agents such as folic acid has the potential to improve patient outcomes; however, comparative data on their effectiveness remains limited. This study aims to determine the clinical outcomes for ischemic stroke patients through folic acid therapy. This study employed a retrospective cohort design using medical records of ischemic stroke patients at X Hospital Yogyakarta between January 2020 and December 2024. Involving 105 patients were included as subjects on this study. The Wilcoxon Signed Rank test is used to analyze how folic acid affected the clinical results in GCS scores. The majority of patients were male (70.5%) and aged ≥60 years (69.5%). All patients had comorbidities (100%). Most patients had initial GCS scores of 14–15, which improved after recieved folic acid therapy (35.2%). The Wilcoxon Signed Rank test showed a significant impact between pre and post GCS score with an average change in GCS score was 1.54 ± 2.67 and p-value 0.000 (p&lt;0.05). There is a significant effect of folic acid therapy on GCS score, with a notable difference observed between pre- and post- treatment ischemic stroke patients. The average of GCS score difference during treatment was 1.54 ± 2.67, and the p-value was 0.000 (p&lt;0.05). This highlights is folic acid can be used as a neuroprotector for ischemic stroke patient especially on JKN patients.</p> Siti Nur Amaliya Novia Ariani Dewi Copyright (c) 1 01 34 41 https://proceeding.unikal.ac.id/index.php/pic/article/view/2963 Lips are a body part that plays an important role in communication, facial expression, and eating. The skin on the lips is thinner than other parts of the skin, making it more susceptible to dryness and damage from environmental factors such as sunlight, wind, and pollution. Lip health is greatly influenced by hydration, nutrition, and proper care, such as using lip balm to maintain moisture. Sunscreen is a cosmetic product that can physically or chemically inhibit the penetration of UV rays into the skin. The potential or strength of a sunscreen is stated based on the SPF (Sun Protecting Factor) value. Beetroot extract is known to contain flavonoid compounds so that it has the potential as a sunscreen. The purpose of this study was to formulate and evaluate lip balm preparations of 96% ethanol extract of red beetroot (Beta vulgaris L.) with variations in beeswax concentration as sunscreen. The method used in this study was experimental. We extracted red beetroot using the maceration method with 96% ethanol. The lip balm preparation was made into 3 formulas with a cera alba base, namely F1 5%, F2 7.5%, and F3 10%. Testing of lip balm preparations includes organoleptic tests, homogeneity tests, pH easurements, irritation tests, adhesion tests, spreadability tests, moisture tests, preference tests, smear tests, viscosity tests, and SPF tests. Testing of the sunscreen activity of red beetroot extract lip balm was carried out using the UVVis spectrophotometry ansur Putri Kartika Sari Nur Cholis Endriyatno Copyright (c) 1 01 42 48 https://proceeding.unikal.ac.id/index.php/pic/article/view/2965 Pregnancy represents a unique immunological state where maternal immune tolerance must be established to prevent fetal rejection while maintaining protection against pathogens. The dysregulation of this delicate balance can lead to pregnancy complications including implantation failure, preterm birth, pre-eclampsia, and fetal growth retardation. Myeloid differentiation of hematopoietic stem cells plays a crucial role in establishing and maintaining this immunological tolerance during pregnancy. This study aims to critically evaluate the literature and provide an overview of current research regarding myeloid differentiation of hematopoietic stem cells in pregnancy immunological tolerance. PubMed, Scopus Biomedicine, EBSCOhost, Science direct, Embase, Cochrane Library and Web of Science were searched for Sistematic review on myeloid differentiation of hematopoietic stem cells in immune tolerance during pregnancy, myeloid differentiation of hematopoietic stem cells are a cell population involved in the regulation of immune response by means by inhibiting it in pathologies, as well as during pregnancy. The strength of the evidence was rated quality by the rating system “GRADE”. We are independent with respect to the results affected. In this systematic review, we provide an overview of the current literature regarding the differentiation of hematopoietic stem cells into fibroblasts in various tissues. PubMed, Elsevier, and Web of Science (Core Collection) were systematically searched for original articles concerning fibroblast origin after hematopoietic stem cell transplantation in collaboration with a medical information specialist. Our search found 121 studies, of which 45 were analysed for full-text analysis independently, resulting in the inclusion of 10 studies. Myeloid differentiation of hematopoietic stem cells in play an essential role in the immune system during pregnancy and they have a role in maintaining healthy pregnancy. The study will help to better understand immune mechanisms at the maternal-fetal interface. Unravelling how the fetal tissue is accepted in pregnancy will provide information for the field of fertility, obstetrics, and differentiation Firstca Aulia Rachma Winnie Kristiyanti Danik Sulistyoningsih Ranatri Puruhita Yovita Dwi Arini Copyright (c) 1 01 49 62 https://proceeding.unikal.ac.id/index.php/pic/article/view/2966 Indonesia is a country rich in biodiversity, with numerous natural sources exhibiting antioxidant activity. One class of bioactive compounds known to contribute to antioxidant properties is phenolics. Clitoria ternatea L. (butterfly pea) flowers are known to contain high levels of phenolic compounds. To extract these compounds effectively, suitable extraction methods are required— one of which is Ultrasound-Assisted Extraction (UAE). In UAE, the choice of solvent plays a critical role, as phenolic compounds are polar and thus require polar solvents for efficient extraction. Ethanol and water are commonly used polar solvents. The composition of the extraction solvent significantly influences the amount of phenolic compounds extracted, necessitating analysis to determine the optimal solvent ratio. This study investigates the effect of different solvent compositions—100% ethanol, 50:50 ethanol:water, and 100% water—on the total phenolic content extracted from Clitoria ternatea L. flowers using the UAE method. The phenolic content was determined using UV-Visible spectrophotometry. Statistical analysis showed a significant difference (ɑ < 0.05) among the three solvent systems, with the highest phenolic yield obtained using a 50:50 ethanol:water mixture, reaching 46.188 ± 0.202 mg GAE/g. These findings indicate that solvent composition plays a key role in optimizing phenolic extraction from butterfly pea flowers Rizqa Salsabila Firdausia Azka Muhammad R Lisman Septa Ardianto Rikhaturhohmah Copyright (c) 1 01 63 67 https://proceeding.unikal.ac.id/index.php/pic/article/view/2967 Sunflower seed oil and virgin coconut oil (VCO) have important benefits for the skin, making them attractive ingredients in liquid soap formulations. Sunflower seed oil contains vitamin E and essential fatty acids that maintain skin moisture and health, while VCO has antimicrobial, antioxidant, and skin softening properties. The combination of these two oils is expected to produce a liquid soap with superior quality in terms of softness, moisture, and skin cleansing. This study aims to find the optimal formulation by testing the physical properties and stability of various liquid soaps containing the combination for maximum benefits for the skin. VCO oil using a combination of sunflower seed oil is formulated in the form of a liquid soap preparation with variations in the addition of sunflower seed oil F0 base, F1 5 ml, F2 10 ml, F3 15 ml and K +. The liquid soap preparation was tested for physical properties such as organoleptic tests, pH tests, homogeneity tests, viscosity tests, foam height tests and physical stability tests. Organoleptic tests showed that F0 was clear, F1 was clear cloudy, F2 was cloudy, F3 was pale yellow, and K + was light brown, all in the form of homogeneous liquids with a distinctive aroma. The pH test showed that F0 had a pH of 8.5; F1 and F2 pH 8.3; F3 pH 8.2; and K+ pH 9.3. All formulations were homogeneous. The viscosity test was consecutive: F0 664.1 mPa.s, F1 556.6 mPa.s, F2 426.1 mPa.s, F3 981.5 mPa.s, K+ 475.6 mPa.s. The foam height was consecutive: F0 56 mm, F1 59 mm, F2 59 mm, F3 56 mm, K+ 59 mm. The physical stability of all formulations did not show significant changes in organoleptic, pH, foam height, homogeneity, and viscosity. The making of liquid soap with a combination of sunflower seed oil and VCO showed changes in physical properties such as viscosity, pH, and foam power, but these changes were not significant. This combination remains stable and effective for liquid soap formulations Sri Fitrianingsih Irvan Kurniawan Hasty Martha Wijaya Copyright (c) 1 01 68 74 https://proceeding.unikal.ac.id/index.php/pic/article/view/2968 The use of antibiotics without a prescription remains a significant public health issue in Indonesia. Misperceptions and lack of knowledge about antibiotics are the main causes of the practice of using antibiotics without a prescription which is at risk of bacterial resistance. This study aims to evaluate the effectiveness of health education provided by pharmacists in improving public perception and knowledge about the proper use of antibiotics. This study used a one-group pre-test and post-test design to 53 respondents in Kluwih village, Batang district, Central Java. The instrument used was a perception questionnaire (Linkert scale) and knowledge (Guttman scale). Data analysis was conducted using paired samples t-test using SPSS software. The results showed a significant increase in perception and knowledge scores after health education with a significance value of 0,000 (p-value <0.05). Participatory health education has been proven effective in increasing public understanding of rational antibiotic use and has the potential to reduce the practice of using antibiotics without a prescription Kholifatur Rohmah Musa Fitri Fatkhiya Copyright (c) 1 01 75 78 https://proceeding.unikal.ac.id/index.php/pic/article/view/2969 Dry skin is one of the most common problems, where dry skin looks dull and rough. Therefore, it is necessary to prepare a moisturizing cream that can be obtained from watermelon (Citrullus lanatus (Thunb.) Matsum. & Nakai) which has antioxidant activity in the form of flavonoids. This studi aims to formulate the watermelon extract (Citrullus lanatus (Thunb.) Matsum. & Nakai) into fresh cream preparations of watermelon extract (Citrullus lanatus (Thunb.) Matsum. & Nakai) as antioxidants with varying concentrations of F1 (base), F2 (5%), and F4 (15%). This type of research is experimental with a post test design with control with group design. The sample is Watermelon purchased at the Jepara Mayong Market. This research process uses water extract, namely fresh fruit juice thickened with a water bath thermostat at a temperature of 80⁰C. Determination of antioxidant activity was carried out using UV-Vis spectrophotometry using the DPPH (1,1-diphenyl-2-picrylhidrazil) method using quercetin as a comparison solution. Phytochemical screening of watermelon extract (Citrullus lanatus (Thunb.) Matsum. & Nakai) was positive for flavonoids, saponons and sucrose. The content of watermelon extract used for the antioxidant activity test was flavonoids. Watermelon (Citrullus lanatus (Thunb.) Matsum. & Nakai) fruit extract has moderate antioxidant activity with an IC50 of 143,93 µg/ml. formulated into a moisturizing cream has weak antioxidant activity IC50 at F1, F2, F3, and F4 respectively 552,09 µg/ml, 451,50 µg/ml and 387,26 µg/ml. The study shows that watermelon extract (Citrullus lanatus (Thunb.) Matsum. & Nakai) has moderate antioxidant activity and can be formulated into a moisturizing cream for watermelon extrac Dessy Erliani Mugita Sari Devia Damayanti Luvita Gabriel Zulkarya Copyright (c) 1 01 79 88 https://proceeding.unikal.ac.id/index.php/pic/article/view/2970 Community-acquired pneumonia (CAP) is the 3rd largest lower respiratory tract infection that causes death in the world. Treatment therapy that is generally used to treat pneumonia is by administering antibiotics. Irrational use of antibiotics can lead to less effective treatment, decreased drug safety, and increased resistance. This study aims to evaluate the rationality of using antibiotics in community-acquired pneumonia patients at UNS Hospital using the Gyssens method in 2021-2022. This research is a non-experimental research with a descriptive design and purposive sampling technique. Data collection was carried out retrospectively with a sample size of 19 patients who were hospitalized in 2021-2022. The data obtained were analyzed descriptively with the Gyssens assessment. The references used are Regulation of the Minister of Health Republic Indonesia Number 28, 2021 concerning Guidelines for the Use of Antibiotics, Guidelines for the Diagnosis of Community Pneumonia and Its Management in Indonesia 2014, UNS Hospital Drug Formulary, NICE Public Health Guidance 2022, and Dipiro 2020. The results of this study showed that 90.47% of patients received rational antibiotic therapy and 9.53% received irrational antibiotic therapy. Rational antibiotic therapy is an antibiotic that is included in category 0. The irrational use of antibiotics in this study is an antibiotic that is included in the IVC category (there are cheaper alternative antibiotics). Erika Dyah Pramesti Lusia Murtisiwi Truly Dian Anggraini Copyright (c) 1 01 89 95