Pregnancy represents a unique immunological state where maternal immune tolerance must be
established to prevent fetal rejection while maintaining protection against pathogens. The dysregulation
of this delicate balance can lead to pregnancy complications including implantation failure, preterm birth,
pre-eclampsia, and fetal growth retardation. Myeloid differentiation of hematopoietic stem cells plays a
crucial role in establishing and maintaining this immunological tolerance during pregnancy. This study
aims to critically evaluate the literature and provide an overview of current research regarding myeloid
differentiation of hematopoietic stem cells in pregnancy immunological tolerance. PubMed, Scopus
Biomedicine, EBSCOhost, Science direct, Embase, Cochrane Library and Web of Science were searched
for Sistematic review on myeloid differentiation of hematopoietic stem cells in immune tolerance during
pregnancy, myeloid differentiation of hematopoietic stem cells are a cell population involved in the
regulation of immune response by means by inhibiting it in pathologies, as well as during pregnancy. The
strength of the evidence was rated quality by the rating system “GRADE”. We are independent with
respect to the results affected. In this systematic review, we provide an overview of the current literature
regarding the differentiation of hematopoietic stem cells into fibroblasts in various tissues. PubMed,
Elsevier, and Web of Science (Core Collection) were systematically searched for original articles
concerning fibroblast origin after hematopoietic stem cell transplantation in collaboration with a medical
information specialist. Our search found 121 studies, of which 45 were analysed for full-text analysis
independently, resulting in the inclusion of 10 studies. Myeloid differentiation of hematopoietic stem cells
in play an essential role in the immune system during pregnancy and they have a role in maintaining
healthy pregnancy. The study will help to better understand immune mechanisms at the maternal-fetal
interface. Unravelling how the fetal tissue is accepted in pregnancy will provide information for the field
of fertility, obstetrics, and differentiation
