THE ROLE OF MYELOID DIFFERENTIATION OF HEMATOPOIETIC STEM CELLS IN PREGNANCY IMMUNOLOGICAL TOLERANCE : A SYSTEMATIC REVIEW

Abstrak

Pregnancy represents a unique immunological state where maternal immune tolerance must be established to prevent fetal rejection while maintaining protection against pathogens. The dysregulation of this delicate balance can lead to pregnancy complications including implantation failure, preterm birth, pre-eclampsia, and fetal growth retardation. Myeloid differentiation of hematopoietic stem cells plays a crucial role in establishing and maintaining this immunological tolerance during pregnancy. This study aims to critically evaluate the literature and provide an overview of current research regarding myeloid differentiation of hematopoietic stem cells in pregnancy immunological tolerance. PubMed, Scopus Biomedicine, EBSCOhost, Science direct, Embase, Cochrane Library and Web of Science were searched for Sistematic review on myeloid differentiation of hematopoietic stem cells in immune tolerance during pregnancy, myeloid differentiation of hematopoietic stem cells are a cell population involved in the regulation of immune response by means by inhibiting it in pathologies, as well as during pregnancy. The strength of the evidence was rated quality by the rating system “GRADE”. We are independent with respect to the results affected. In this systematic review, we provide an overview of the current literature regarding the differentiation of hematopoietic stem cells into fibroblasts in various tissues. PubMed, Elsevier, and Web of Science (Core Collection) were systematically searched for original articles concerning fibroblast origin after hematopoietic stem cell transplantation in collaboration with a medical information specialist. Our search found 121 studies, of which 45 were analysed for full-text analysis independently, resulting in the inclusion of 10 studies. Myeloid differentiation of hematopoietic stem cells in play an essential role in the immune system during pregnancy and they have a role in maintaining healthy pregnancy. The study will help to better understand immune mechanisms at the maternal-fetal interface. Unravelling how the fetal tissue is accepted in pregnancy will provide information for the field of fertility, obstetrics, and differentiation